The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA

李梦东; 何长清; 郑智勇; 程懋坪

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The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA

Updated：2026-03-12

- The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA
- The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA
- 解放军医学杂志（英文版） 1986年第2期页码：154-158
- Affiliations：
  
  1. Department of Infectious Disease Second Teaching Hospital
  2. Third Military Medidal College
  3. ,Chongqing
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1986
- Accepted：
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The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA[J]. 解放军医学杂志（英文版）, 1986,(2):154-158.

[1]李梦东,何长清,郑智勇,程懋坪.The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA[J].Journal of Medical Colleges of PLA,1986(02):154-158.
The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA[J]. 解放军医学杂志（英文版）, 1986,(2):154-158. DOI：

[1]李梦东,何长清,郑智勇,程懋坪.The Clinical Significance of Anti-LSP Antibodies in the Sera of Patients with Viral Hepatitis:An Evaluation with ELISA and SPA-RIA[J].Journal of Medical Colleges of PLA,1986(02):154-158. DOI：

摘要

Abstract

<正> Antibodies against LSP in the sera of 163 patients with various typesof viral hepatitis were determined with SPA-RIA.The sera of anothergroup of 118 patients（109 of them were from the first group）withviral hepatitis were studied with ELISA for the same antibodies

whichwere further divided into three categories

that is

IgG

IgM

and IgAclasses.The results of 109 patients examined with both of the two me-thods indicated that anti-LSP antibodies measured by SPA-RIA mightmainly represent anti-LSP IgG class.It was found that circulating anti-LSP antibodies could easily be detected in most patients with either acuteor chronic hepatitis.After analyzing the results

the authors suggest thatthe humoral immune response against LSP might not be the sole initiatingfactor in the pathogenesis of viral hepatitis

they are more likely theresult of the antigen variation of the injured liver cells.

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