Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases

宋静澄; 何杏; 周芷芬; 张肇和

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Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases

Updated：2026-03-12

- Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases
- Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases
- 解放军医学杂志（英文版） 1987年第3期页码：249-253
- Affiliations：
  
  1. Department of Pediatrics First Military Medical College
  2. ,Guangzhou
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1987
- Accepted：
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Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases[J]. 解放军医学杂志（英文版）, 1987,(3):249-253.

[1]宋静澄,何杏,周芷芬,张肇和.Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases[J].Journal of Medical Colleges of PLA,1987(03):249-253.
Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases[J]. 解放军医学杂志（英文版）, 1987,(3):249-253. DOI：

[1]宋静澄,何杏,周芷芬,张肇和.Fetal Liver Transplantation in the Treatment of β-Thalassemia Major:Report of Two Cases[J].Journal of Medical Colleges of PLA,1987(03):249-253. DOI：

摘要

Abstract

正

Two cases of β-thalassemia major treated with fetal liver transplanta-tion（FLT）were reported.A conditioning regimen of total body irradiation pluscyclophosphamide was given

followed by the infusion of suspensions of fetal livercells.The number of nucleated cells（procared from 3 to 4 fetal livers）infused tothe 2 cases was 17.5 and 15.5×10

/kg respectively.Transient hemopoieticdepression was observed after FLT

and normal hemopoiesis was recoveredaround the 30th day.Karyotypic analysis revealed that the donor typechromosomes was founed in the peripheral blood of both cases from the 20th dayto 123rd day after FLT.Skin biopsy of cass 1 revealed changes of mild GVHD

indicating engrafment of fetal hemopoietic cells and formation of chimeras in thisperiod.Autologous hemopoiesis was reconstituted in both cases two months afterFLT.Blood transfusion was not necessary within the first 5 months after FLT

and in case 1 transfusion was given 3 times only within 21 months after FLT.

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