Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning

王家政; 顾如英; 侯宁; 王玉民; 王克为

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Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning

Updated：2026-03-12

- Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning
- Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning
- Military Medical Research 1986年第4期页码：392-396
- Affiliations：
  
  Laboratory Fourth Military Medical College.,Xi’an,403
- Author bio：
- Funds：
- DOI：
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- 纸质出版：1986
- Accepted：
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Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning[J]. Military Medical Research, 1986,(4):392-396.

[1]王家政,顾如英,侯宁,王玉民,王克为.Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning[J].Journal of Medical Colleges of PLA,1986(04):392-396.
Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning[J]. Military Medical Research, 1986,(4):392-396. DOI：

[1]王家政,顾如英,侯宁,王玉民,王克为.Changes of Lactate Dehydrogenase Activity in Airways of Guinea-pigs after Diphosgene Poisoning[J].Journal of Medical Colleges of PLA,1986(04):392-396. DOI：

摘要

Abstract

正

Lactate dehydrogenase（LDH）

as an indicator of cell damageor death

was used to determine the diphosgene damage of respiratorytract cells.Guinea-pigs were exposed to diphosgene at concentrationswithin the LCt

range and above.The content of LDH in thebronchopulmonary washings of guinea-pigs was significantly increa-sed after poisoning.There was no increase of free hemoglobincontent in the washings.It was indicated that lysed erythrocyteswere not the source of LDH in the poisoned group.The LDH iso-enzyme pattern in the poisoned group washings suggests that theincreased LDH comes from the respiratory tract cells.These resultsshow diphosgene can directly damage cells of the respiratory tract.

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