Effects of RNA from H<sub>22</sub>Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro

周辰; 苏成芝; 王兆裕

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Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro

Updated：2026-03-12

- Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro
- Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro
- 解放军医学杂志（英文版） 1986年第3期页码：189-196
- Affiliations：
  
  1. Department of Biochemistry First Military Medical College
  2. ,Guangzhou
  3. Fourth Military Medical College
  4. Xian
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1986
- Accepted：
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Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro[J]. 解放军医学杂志（英文版）, 1986,(3):189-196.

[1]周辰,苏成芝,王兆裕.Effects of RNA from H_(22)Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro[J].Journal of Medical Colleges of PLA,1986(03):189-196.
Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro[J]. 解放军医学杂志（英文版）, 1986,(3):189-196. DOI：

[1]周辰,苏成芝,王兆裕.Effects of RNA from H_(22)Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro[J].Journal of Medical Colleges of PLA,1986(03):189-196. DOI：

摘要

Abstract

正

With cell-mediated

Cr cytotoxicity assay

it was demonstratedthat the RNA extracted from H

tumor cells(H

TuRNA)could.significantly inhibit the cytotoxic effect of lymphocytes of normalmouse spleen when treated with H

TuRNA at a dosage of≥250μg H

TuRNA/1×10

lymphocytes at 37℃ for 60 min.The inten-sity of inhibition depended on the incubation time and the dose ofH

TuRNA.The inhibition capacity was not abolished by treating with:RNase.Polyacrylamide gel electrophoresis showed that only thesmall molecules of RNA with the sedimentation rate about 4sremained after the treatment with RNase.Thus

it was consideredthat the RNA with small molecules which possesses anti-RNaseproperty was one of the active components in H

TuRNA.H

TuRNA could also inhibit the ability of lymphocytes toadhere to glass surfaces.This suggested that the function of H

-TuRNA to inhibit the cytotoxic effect of lymphocytes was to inter-fere with the contact between lymphocytes and target cells.

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Effects of RNA from H22Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro

Effects of RNA from H22Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro

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摘要

Abstract

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references

Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro

Effects of RNA from H₂₂Tumor Cells on the Cytotoxicity of Lymphocytes of Normal Mouse Spleen in vitro