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We studied the changes of pulmonary vascular permeability andlipoperoxides in scalded rats with full-thickness damage 40％ of bow surface. Theresults showed that both pulmonary vascular permeability and lipoperoxides inserum and lung homogenate increased significantly 2 h after scalding.Subsequently

interstitial and alveolar edema developed.Pulmonary vascularpermeability was strongly correlated with lung lipoperoxides（r=0.992）.SerumCH

50

was decreased to 56.8％ 1 h after scalding

and at the same time

neutrophilcount increased in pulmonary interstitium and vasculature.The increase inpulmonary vascular permeability and lipoperoxides could be prevented with largedose of vitamin E and neutropenia.The results indicate that the lipoperoxidationof pulmonary vascular endothelial cells secondary to complement activation andpulmonary leukostasis is the major cause of increase in pulmonary vascularpermeability after scalding.