Beneficial Effects of Nicorandil on Lidocaine Intoxicity

赵德化; 盛宝恒

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Beneficial Effects of Nicorandil on Lidocaine Intoxicity

Updated：2026-03-12

- Beneficial Effects of Nicorandil on Lidocaine Intoxicity
- Beneficial Effects of Nicorandil on Lidocaine Intoxicity
- 解放军医学杂志（英文版） 1987年第3期页码：241-244
- Affiliations：
  
  1. Department of Pharmacology Fourth Military Medical College
  2. ,Xi’an
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1987
- Accepted：
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Beneficial Effects of Nicorandil on Lidocaine Intoxicity[J]. 解放军医学杂志（英文版）, 1987,(3):241-244.

[1]赵德化,盛宝恒.Beneficial Effects of Nicorandil on Lidocaine Intoxicity[J].Journal of Medical Colleges of PLA,1987(03):241-244.
Beneficial Effects of Nicorandil on Lidocaine Intoxicity[J]. 解放军医学杂志（英文版）, 1987,(3):241-244. DOI：

[1]赵德化,盛宝恒.Beneficial Effects of Nicorandil on Lidocaine Intoxicity[J].Journal of Medical Colleges of PLA,1987(03):241-244. DOI：

摘要

Abstract

<正> It was demonstrated that nicorandil 50 and 100 mg/kg intravenously orintraperitoneally could prevent the intoxication of lidocaine and decrease itsmortality rate

furthermore nicorandil 50mg/kg

if combined with 5 mg/kgdiazepam

had a synergetic prophylactic effect against lidocaine toxicity

and thistoxicity could be effectively antagonized by 100 mg/kg of nicorandil in mice.Itwas found that the tolerant dose of lidocaine was elevated by nicorandil 100mg/kg intraperitoneally in rats.

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