Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice

胡友梅; 聂梅

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Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice

Updated：2026-03-12

- Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice
- Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice
- 解放军医学杂志（英文版） 1989年第2期页码：116-119
- Affiliations：
  
  1. Department of Pharmacology Third Military Medical College
  2. ,Chongqing
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1989
- Accepted：
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Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J]. 解放军医学杂志（英文版）, 1989,(2):116-119.

[1]胡友梅,聂梅.Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J].Journal of Medical Colleges of PLA,1989(02):116-119.
Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J]. 解放军医学杂志（英文版）, 1989,(2):116-119. DOI：

[1]胡友梅,聂梅.Protective Effect of Folic Acid on Nitroquine Toxicity to Small Intestine in Mice[J].Journal of Medical Colleges of PLA,1989(02):116-119. DOI：

摘要

Abstract

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One hundred and ninety-five mice were used to study the mechanism of the protective ef-fects of folic acid on nitroqine toxicity to the small intestine.After oral administration of nitroquineacetate（570mg/kg×1）

intramuscular injection of normal saline was given to one group of mice（NS group）and intramuscular injection of folic acid（8mg/kg×1）to another（NF group）.Decrease incells in the crypts were observed in the animals of NS group

but the changes were much milder inthose of NF group even at 96 h after administration.The decrease of DNA content in the tissues ofthe small intestine was dose-and time-dependent.The value of cpm/mg of DNA after

H-TdRincorporation were much higher in NF group than in NS group.these rcsults suggest that DNA synthesis in the small intestine may be promoted by folic acid so thatthe renair of the damaged intestinal mucosa is acoelerated.

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