Studies on the Chemistry of Photocarcinorin

许德余; 殷祥生; 陈雄; 陈文晖; 刘军

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Studies on the Chemistry of Photocarcinorin

Updated：2026-03-12

- Studies on the Chemistry of Photocarcinorin
- Studies on the Chemistry of Photocarcinorin
- 解放军医学杂志（英文版） 1987年第1期页码：7-13
- Affiliations：
  
  1. Laboratory for Antimalarial Drug Research Second Military Medical College
  2. ,Shanghai
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1987
- Accepted：
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Studies on the Chemistry of Photocarcinorin[J]. 解放军医学杂志（英文版）, 1987,(1):7-13.

[1]许德余,殷祥生,陈雄,陈文晖,刘军.Studies on the Chemistry of Photocarcinorin[J].Journal of Medical Colleges of PLA,1987(01):7-13.
Studies on the Chemistry of Photocarcinorin[J]. 解放军医学杂志（英文版）, 1987,(1):7-13. DOI：

[1]许德余,殷祥生,陈雄,陈文晖,刘军.Studies on the Chemistry of Photocarcinorin[J].Journal of Medical Colleges of PLA,1987(01):7-13. DOI：

摘要

Abstract

<正> Here presents a report on the preparation

chemical composition andphysico-chemical properties of photocarcinorin（PsD-007）

a new drug ofphotolocalization and photochemotherapy for human malignancies.It was shownby the results of thin layer and high performance liquid chromatographic（TLC &HPLC）analyses that about 85% of its total weight are relatively hydrophorbicporphyrins of unknown structure

in which a fraction with the same retention timeas hematoporphyrin（Hp）monoacetate constitutes more over 60%.There are also4.2%

of Hp

8.6% of 3（8）-hydroxyethyl-8（3）-vinyl deuteroporphyrin（HVD）and0.6% of protoporphyrin（Pp）in this drug.The presence and amount of HVD inPsD 007 were determined by an authentic sample prepared by authors.Thechanges of the composition of PsD-007 on exposure to different doses of argonlaser（514.5+488nm）irradiation were detected by HPLC.The variations in Soretpeak of UV absorption spectra of PsD-007 protected from light at a constanttemperature were also determined.

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