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Thirteen goats with chronic lung lymph fistula were inflicted withsmoke inhalation injury.Thromboxane A

2

（TXA

2

in terms of thromboxane B

2

orTXB

2

）and prostacyclin(PGl

2

in terms of 6-keto-prostaglandin F

1x

or6-keto-PGF

1

x)in plasma

lung lymph and lung tissue were measured withradioimmunoassay（RIA）.Extravascular lung water（EVLW）

lung lymph flow（QL）

the ratio of protein contents between lung lymph and plasma（LIP）

hemodynamic parameters

blood gases

platelet and leukocyte counts were alsodetermined.EVLW

QL and L/P increased significantly at the 1st hour

reachedtheir peak values at the 2nd hour

then declined gradually and remained at a levelover the baseline at the 6th hour after injury.TXA

2

and PGl

2

also increasedmarkedly and the.changes of TXA

2

and TXA

2

/PGI

2

ratio were in parallel withthose of EVLW

QL and LIP both in degree and in length of time.It is possiblethat the increased TXA

2

and TXA

2

/PGI

2

ratio might participate in the formationof permeability pulmonary edema through direct injury and for chemical mediatorsreleased by platelet and leukocyte aggregations promoted by TXA

2

.In addition

TXA

2

might also play a role in the early elevation of pulmonary arterial pressure.