Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies

彭秀军; 于纯智; 莫简; 孙淑芬

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Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies

Updated：2026-03-12

- Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies
- Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies
- 解放军医学杂志（英文版） 1989年第4期页码：299-302
- Affiliations：
  
  1. Department of Ophthalmology Xijing Hospital
  2. Department of Chemistry
  3. Fourth Military Medical University
  4. ,710032
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1989
- Accepted：
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Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies[J]. 解放军医学杂志（英文版）, 1989,(4):299-302.

[1]彭秀军,于纯智,莫简,孙淑芬.Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies[J].Journal of Medical Colleges of PLA,1989(04):299-302+382.
Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies[J]. 解放军医学杂志（英文版）, 1989,(4):299-302. DOI：

[1]彭秀军,于纯智,莫简,孙淑芬.Relationship between Copper-Induced Lipid Peroxidation and Retinal Damage in Intraocular Copper Foreign Bodies[J].Journal of Medical Colleges of PLA,1989(04):299-302+382. DOI：

摘要

Abstract

<正> At different

time after copper wire induced into the vitreous of the rabbits

malondialdehydes（MDA）in the retinas and trace element coppar in the aqueous humor and Pa-thology were observed.One day after the induction of copper

the level of MDA increasedabout three times in the retinas of experimental eyes as compared with the control eyes（p<0.01）and the amplitude of electroretinography（ERG）dropped rapidily following increase ofcopper ions in the vitreous.The tncrease of concentration of copper ions in the vitreous wasclosely correlated with that of MDA in the retinas （p<0.01）.Early EM examination of ex-perimental eyes reveaisd damage of retinal membranous structure rich in oxygen andpolyunsaturated acid（PUFA）

including the ovaer and inner segments of the photoreceptors.These results indicate thu copper-induced isptd peroxidation is an important cause of retinaldumage.

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