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正

>

Experiments to investisate the effects of soman on lymphocyte proliferation werecarried out on balb/c mice

which were injected subcutaneously with soman in the doseof 154μg/kg (0.8 LD

50

)

96μg/kg (0.5 LD

50

) and 38.4μg/kg (0.2 LD

50

) respectively.Itwas found that from the 1st to the 7th day after poisoning with 154μg/kg soman

B-lymphocyte proliferation was severely inhibited （P

<

0.05）

and it returned to the controllevel on the 10th day.Con A-stimulated T-cell proliferation showed a diphasic change

increasing at first and then markedly decreasing thereafter

after soman poisoning.The re-sults imply that the mitogenic response of both B- and T- cells and the primary increaseof T- cell response are closely related to the dosage of soman but not with the changes ofwhole blood cholinesterase activity.