Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007
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Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007
Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007
解放军医学杂志(英文版)1987年第4期 页码:323-327
Affiliations:
1. Department of Pathology Fourth Military Medical College Xi’an
3. Radiology Institute Academy of Military Medical Sciences Beijing
Author bio:
Funds:
DOI:
中图分类号:
纸质出版:1987
Accepted:
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Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007[J]. 解放军医学杂志(英文版), 1987,(4):323-327.
[1]王福安,刘彦仿,丁华野,陈定一.Treatment of H_(22) Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007[J].Journal of Medical Colleges of PLA,1987(04):323-327+396.
Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007[J]. 解放军医学杂志(英文版), 1987,(4):323-327.DOI:
[1]王福安,刘彦仿,丁华野,陈定一.Treatment of H_(22) Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007[J].Journal of Medical Colleges of PLA,1987(04):323-327+396.DOI:
Treatment of H22 Hepatoma Transplanted in Mice by Radiotherapy and Carcinophotorin PSD-007
摘要
Abstract
<
正
>
Three days after I.M. inoculation of ascitic H
22
hepatoma cellsinto the thighs of Kunming strain mice (1.5 × 10
7
cells/mouse)
the animalswere given I. P. injections of PSD - 007 in a dosage of 20 g/g body weight10 - 12 hr prior to x - radiation. It was found that 15 Gy radiationcombined with PSD - 007 promoted the tumor regression more significantlythan 15 Gy radiation alone
and that the therapeutic efficacy was 1.44 timesof the latter. In the combined group
it was histologically confirmed thatmore severe tumor injury was typified by copious degenerated tumor giantcells. The damage to karyolemma and mitochondria appeared earlier andmore serious. The results suggest that PSD - 007 has a goodradiosensitizing potential
and that the membranous structures may be thetarget site of sensitization by PSD 007.
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