Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro

钱月明; 黄钺华

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Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro

Updated：2026-03-12

- Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro
- Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro
- 解放军医学杂志（英文版） 1988年第2期页码：140-143
- Affiliations：
  
  1. Department of Pharmacology Third Military Medical College
  2. ,Chongqing
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1988
- Accepted：
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Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro[J]. 解放军医学杂志（英文版）, 1988,(2):140-143.

[1]钱月明,黄钺华.Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro[J].Journal of Medical Colleges of PLA,1988(02):140-143+208.
Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro[J]. 解放军医学杂志（英文版）, 1988,(2):140-143. DOI：

[1]钱月明,黄钺华.Effects of Tetrandrine on Rabbit Platelet Morphology and Aggregation in vitro[J].Journal of Medical Colleges of PLA,1988(02):140-143+208. DOI：

摘要

Abstract

正

Using turbidimetry and electronmicroscopy

we examined the effects oftetrandrine （Tet） on the aggregation and morphological changes of rabbit platelets.It wasfound that Tet could markedly inhibit the platelet aggregation induced by ADP

collagenand arachidonic acid （AA） in a dose-dependent manner.The IC

（50% inhibitoryconcentration） was 38.9

30.3 and 44.3μg/ml respectively.The platelets pretreated with Tetcould not be activated by collagen

their morphological changes and granule release didn’toccur and their normal structure was well preserved.In addition

dipyridamole couldenhance the inhibition of Tet on platelet aggregation

while increased extracellular calciumcould weaken this inhibition.

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