Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome

汪美先; 徐志凯; 许辉; 张红毅; 汪力亚; 安献禄

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Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome

Updated：2026-03-12

- Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome
- Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome
- 解放军医学杂志（英文版） 1989年第1期页码：1-4
- Affiliations：
  
  Department of Microbiology Fourth Military Medical University Xi’an
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- 纸质出版：1989
- Accepted：
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Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome[J]. 解放军医学杂志（英文版）, 1989,(1):1-4.

[1]汪美先,徐志凯,许辉,张红毅,汪力亚,安献禄.Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome[J].Journal of Medical Colleges of PLA,1989(01):1-4.
Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome[J]. 解放军医学杂志（英文版）, 1989,(1):1-4. DOI：

[1]汪美先,徐志凯,许辉,张红毅,汪力亚,安献禄.Study and Application of Monoclonal Antibodies against Virus of Haemorrhagic Fever with Renal Syndrome[J].Journal of Medical Colleges of PLA,1989(01):1-4. DOI：

摘要

Abstract

<正> This paper summarizes the study and application of monoclonal antibodies （McAbs）against haemorrhagic fever with renal syndrome （HFRS） virus in our department over the past sever-al years. The following six points are discussed: （1） establishment and characterization of thehybridoma cell lines secreting McAbs against HFRS virus and hemagglutinin of the virus: （2） theantigenic analysis of HFRS viruses in China by McAbs: （3） purification and application of theMcAbs: （4） purification and characterization of HFRS virus 50K stnactural protein by McAba-affini-ty chromatography and the McAbs possessing different characteristics: （5） detection of HFRS virusantigen in peripheral blood lymphocytes from HFRS patients by the McAb-IFAT; and （6）development of McAb-ELISA indirect sandwich methods

and detection of HFRS virus antigen andIgM

IgG and/or HI antibodies in human and animals. The results of the studies show that theMcAbs can be used for early diagnosis

epidemiological investigation

preparation of vaccine andimmunotherapy of HFRS.

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