The glucocorticoid resistance in burn and shock

徐仁宝

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The glucocorticoid resistance in burn and shock

Updated：2026-03-12

- The glucocorticoid resistance in burn and shock
- The glucocorticoid resistance in burn and shock
- 解放军医学杂志（英文版） 1991年第4期页码：388-395
- Affiliations：
  
  1. Department of Pathophysiology Second Military Medical University
  2. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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The glucocorticoid resistance in burn and shock[J]. 解放军医学杂志（英文版）, 1991,(4):388-395.

[1]徐仁宝.The glucocorticoid resistance in burn and shock[J].Journal of Medical Colleges of PLA,1991(04):388-395.
The glucocorticoid resistance in burn and shock[J]. 解放军医学杂志（英文版）, 1991,(4):388-395. DOI：

[1]徐仁宝.The glucocorticoid resistance in burn and shock[J].Journal of Medical Colleges of PLA,1991(04):388-395. DOI：

摘要

Abstract

正

The changes of glucocorticoid receptor （GR） and the reactivity of target cells toglucocorticoids （GC） were studied experimentally.The results showed that GC resistance

which wascaused mainly by the decrease of GR

developed in burned and shocked rats and dogs.Thesechanges may exacerbate the shock state

and even lead to the development of multiple organfailuue.The protection of GC against intestinal ischemic shock of dogs was demonstrated after theconcentration of dexamethasone （Dex） in plasma was elevated to 10

-6

mol/L by iv injection of 5mgDex/kg body weight.

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