Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone

韩亚玲; 祝善俊; 王一健

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Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone

Updated：2026-03-12

- Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone
- Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone
- 解放军医学杂志（英文版） 1990年第3期页码：291-295
- Affiliations：
  
  1. Department of Cardioangiology Xinqiao Hospital
  2. and Central Lab
  3. Third Military Medical College
  4. .,Chongqing,630038
  5. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1990
- Accepted：
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Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone[J]. 解放军医学杂志（英文版）, 1990,(3):291-295.

[1]韩亚玲,祝善俊,王一健.Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone[J].Journal of Medical Colleges of PLA,1990(03):291-295+299.
Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone[J]. 解放军医学杂志（英文版）, 1990,(3):291-295. DOI：

[1]韩亚玲,祝善俊,王一健.Relationship of Intralymphocytic Cyclic Nucleotide and Calcium Ion Changes with Cardiac Function in Congestive Heart Failure Patients Treated with Amrinone[J].Journal of Medical Colleges of PLA,1990(03):291-295+299. DOI：

摘要

Abstract

正

The contents of intralymphocytic cyclic nucleotide（cAMP and cGMP）and cal-cium ions(Ca

)were determined in 20 patients with refractory congestive heart failure be-fore and after the treatment of Chinese-made amrinone

and their cardiac index was alsomcasured with the thermodilution technique.It was found that the cAMP andCa

contents were markedly elevated while the cardiac index increased under amrinonctreatment

and that both the cAMP and Ca

ontents were in positive correlation withthe cardiac index before and after amrinone administration.It is suggested that amrinone is likcly to exert its positive inotropic effect on themyocardium through augmenting the cAMP and Ca

contents in myocardial cells

andthat the determination of intralymphocytic cyclic nuclcotidc and Ca

might bc of signifi-canoe to assess the impairment of cardiac function and the cfficacy of a thcrapcuticagent.

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