A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues

高峰; 牛国保; 臧益民; 叶建明; 施溥涛

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A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues

Updated：2026-03-12

- A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues
- A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues
- 解放军医学杂志（英文版） 1989年第3期页码：196-199
- Affiliations：
  
  1. Department of Physiology University Xi’anXijing Hospital Fourth Military Medical
  3. Department of Laboratory Xijing Hospital Fourth Military Medical University Xi’an
  4. Shanghai Biochemistry Institute Chinese Academy of Sciences Shanghai
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1989
- Accepted：
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A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues[J]. 解放军医学杂志（英文版）, 1989,(3):196-199.

[1]高峰,牛国保,臧益民,叶建明,施溥涛.A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues[J].Journal of Medical Colleges of PLA,1989(03):196-199.
A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues[J]. 解放军医学杂志（英文版）, 1989,(3):196-199. DOI：

[1]高峰,牛国保,臧益民,叶建明,施溥涛.A Comparative Study on Hypotensive and Diuretic Effects of Atriopeptin III and its Analogues[J].Journal of Medical Colleges of PLA,1989(03):196-199. DOI：

摘要

Abstract

正

In order to find atriopeptin （AP） analogues with more potent and longer-lasting effects

we have synthesized rat APⅢ and its three analogues A1

and assayed their bioactivitiesin anesthetized rats. The results demonstrate that the synthesized APⅢ has powerful diuretic

natriuretic effects

and can remarkably lower arterial blood pressure

while the heart rote remainsunchanged in the process. The aforementioned effects of APⅢ are dose-dependent. The hypotensionof APⅢ is independent of the diuresis caused by APⅢ. The three analogues’ of APⅢ are all 24peptides. A

and A

had no bioactivities

while A

possessed atriopeptin-like

but weaker activities.The results suggest that the 5th

6th and 7th amino add residues and their configurations in thepeptide chain of AP Ⅲ are crucial for eliciting bioactivities.

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