In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells

汪森明; 陈希陶; 张学庸; 樊代明

Your Location：

Home >

Browse articles >

In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells

Updated：2026-03-12

- In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells
- In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells
- 解放军医学杂志（英文版） 1991年第4期页码：324-327
- Affiliations：
  
  1. Department of Gastroenterology Zhujiang Hospital
  2. First Military
  3. Medical University
  4. ,Xi’an,710032
  5. Laboratory of Gastroenterology
  6. Xijing Hospital
  7. Fourth Military Medical University
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
Scan QR Code
In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells[J]. 解放军医学杂志（英文版）, 1991,(4):324-327.

[1]汪森明,陈希陶,张学庸,樊代明.In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells[J].Journal of Medical Colleges of PLA,1991(04):324-327+331.
In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells[J]. 解放军医学杂志（英文版）, 1991,(4):324-327. DOI：

[1]汪森明,陈希陶,张学庸,樊代明.In vitro effects of monoclonal antibody targeted daunomycin on human gastric cancer cells[J].Journal of Medical Colleges of PLA,1991(04):324-327+331. DOI：

摘要

Abstract

正

In the present study

daunomydn （DIM） was chosen to conjugate cowdently with amonoclonal antitibody

MGb

against human gastric cancer cells via a cis-aconitic anhydride linker（directly） or a dextmn bridge （indirectly

） The mo-lar ratio of MGb

to DM in the conjugates was1:6 （direct method） and 1:54 （indirect method）

respectively.The ELISA results revealed theantibody after conjugation retained antigen-binding capacity.The conjugates showed a highly se-lective cytotoxicity to the target cells.In lh cytotoxidty test

cytotoxidty of the conjugates wasgreater than that of free DM or irrevalent conjugates to human gastric cancer cell lines

SGC-7901and very low as far as non-target cells （HeLa） were concerned.It is sugared that theselective cytotoxidty on target cells of the conjugates is mediated by the monoclonal antibody.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据