A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice

耿怡; 麦智广; 丁振海

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A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice

Updated：2026-03-12

- A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice
- A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice
- 解放军医学杂志（英文版） 1989年第2期页码：146-150
- Affiliations：
  
  1. Department of Radiation Medicine Second Military Medical University
  2. ,Shanghai
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1989
- Accepted：
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A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice[J]. 解放军医学杂志（英文版）, 1989,(2):146-150.

[1]耿怡,麦智广,丁振海.A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice[J].Journal of Medical Colleges of PLA,1989(02):146-150.
A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice[J]. 解放军医学杂志（英文版）, 1989,(2):146-150. DOI：

[1]耿怡,麦智广,丁振海.A Crude Preparation of Lymphocyte Chalone and Its Suppressive Effect on Immune Function in Mice[J].Journal of Medical Colleges of PLA,1989(02):146-150. DOI：

摘要

Abstract

正

A crude preparation of lymphocyte chalone was extracted from calf Spleen using coldaoctone and distilled water.Its inhibitory cffect on mouse lymphocyte proliferation was demonstratedby

H-TdR incorporation method in vitro.This extract shoed no inhibitory effect on the

H-TdR uptake of K

62 cells and displayed no cytotoxicity to mouse lymphocyte

suggesting thatthere existed the activity of lymphocytc chalone in the extract.The crude chalone inhibited

H-TdRuptake of mouse lymphocyte stimulated with concanavalin A（Con A）and mixed lymphocytc re-sponse（MLR）

and the degree of the inhibition was greater as the doses of the extract in culturesbecame higher

indicating it had inhibitory effect on T lymphocytes Its influence on the numbers ofrosette-forming cells（RFC）and plaque-forming cells（PFC）in the spleen of mice revealed that ithad inhibitory effocts on some stages of immunization

including the actions on T and B lymphocytes

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