An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis

罗丁; 韩本立; 龚建平; 段恒春; 李昆

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An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis

Updated：2026-03-12

- An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis
- An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis
- 解放军医学杂志（英文版） 1991年第4期页码：319-323
- Affiliations：
  
  1. Department of Hepatobiliary Surgery Southwest Hospital
  2. Third Military Medical College
  3. ,Chongqing,630033
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China,No.38870770
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J]. 解放军医学杂志（英文版）, 1991,(4):319-323.

[1]罗丁,韩本立,龚建平,段恒春,李昆.An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J].Journal of Medical Colleges of PLA,1991(04):319-323.
An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J]. 解放军医学杂志（英文版）, 1991,(4):319-323. DOI：

[1]罗丁,韩本立,龚建平,段恒春,李昆.An experimental study on hepatocyte mitochondrion damage during acute biliary sepsis[J].Journal of Medical Colleges of PLA,1991(04):319-323. DOI：

摘要

Abstract

<正> In order to elucidate the mechanism of liver damage due to acute biliary sepsis

thechanges of hepatocyte mitochondria were observed during biliary sepsis in the rot.Mitochondrial cal-cium content

lysosome fragility of the hepatocytes

lipid peroxide （LPO） level of fiver tissue

omithine carbamyltransferase （OCT）

mitochondrial glutamic-oxaloacetic transaminase （m-GOT） andhepatoplastin were determined.It was found that there were overloading of calcium in mitochondria

increase of lysosome fragility

and accumulation of LPO in the liver.These events would result inadverse effects on mitochondrial function The activity of OCT and m-GOT was significantly in-creased

which suggests that mitochondria are seriously damaged since the 2 enzymes mainly comefrom hepatocyte mitochondria.And the liver reserving function declined progressively.Our study indi-cates that mitochondrial damage does exist during acute biliary sepsis

which might playan important role in liver damage.

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