Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers

侯金林; 骆抗先; 章廉

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Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers

Updated：2026-03-12

- Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers
- Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers
- 解放军医学杂志（英文版） 1991年第4期页码：366-369
- Affiliations：
  
  1. Department of Infectious Diseases Nan fang Hospital
  2. First Military Medical University
  3. ,Guangzhou,510515
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers[J]. 解放军医学杂志（英文版）, 1991,(4):366-369.

[1]侯金林,骆抗先,章廉.Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers[J].Journal of Medical Colleges of PLA,1991(04):366-369+373.
Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers[J]. 解放军医学杂志（英文版）, 1991,(4):366-369. DOI：

[1]侯金林,骆抗先,章廉.Correlation between expression of HLA class Ⅱ antigen on hepatocyte membrane and viral replication in chronic hepatitis B virus carriers[J].Journal of Medical Colleges of PLA,1991(04):366-369+373. DOI：

摘要

Abstract

<正> In order to study the relationship between replicative status and human leucocyte antigens（HLA）

HLA class Ⅱ antigen on hepatocyte membrane was analyzed in liver biopsies from 49 pa-tients with chronic hepatitis B virus infection.The results revealed that expression of HLA classⅡ antigen on hepatocyte membrane was observed in 57% （13/23） of hepatitis B e antigen （HBeAg）positive

only in 15% （4/26） of anti-HBe positive carriers.The display of HLA class Ⅱ antigen onhepatocyte membrane yeas found in 65% （11/17） hepatitis B core antigen （HBcAg） positive and in19% （6/32） HBcAg negative patients with chronic hepatitis B virus infection.There was nosignificant difference in the expression of HLA class Ⅱ antigen on hepatocyte membrane between mi-nor hepatic diseases and active liver diseases.These findings suggested that display of HLA classⅡ antigen on hepatocyte membrane might be associated with viral replication in the chronic hepati-tis B virus carriers.

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