Tumor localization of anti-gastric cancer monoclonal antibody MGb<sub>2</sub>-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

陈敏; 黎松; 邓敬兰; 张学庸; 陈希陶

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Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

Updated：2026-03-12

- Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901
- Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901
- 解放军医学杂志（英文版） 1992年第1期页码：81-83
- Affiliations：
  
  1. Department of Nuclear Medicine Xijing Hospital Fourth Military Medical University
  2. ,Xi’an,710032
  3. Laboratory of Gastroenterology
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901[J]. 解放军医学杂志（英文版）, 1992,(1):81-83.

[1]陈敏,黎松,邓敬兰,张学庸,陈希陶.Tumor localization of anti-gastric cancer monoclonal antibody MGb_2-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901[J].Journal of Medical Colleges of PLA,1992(01):81-83.
Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901[J]. 解放军医学杂志（英文版）, 1992,(1):81-83. DOI：

[1]陈敏,黎松,邓敬兰,张学庸,陈希陶.Tumor localization of anti-gastric cancer monoclonal antibody MGb_2-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901[J].Journal of Medical Colleges of PLA,1992(01):81-83. DOI：

摘要

Abstract

正

In the present study

an anti-gastric cancer monoclonal antibody MGb

-daunomycin（DM）conjugate was prepared by cis-aconitic anhydride method.The distribution of the conjugatein nude mice bearing human gastric carcinoma SGC-7901 was investigated.Four to five moleculesof DM were introduced into each molecule of antibody while the antigen-binding capacity ofthe antibody was well-retained.This conjugate could be satisfactorily localized in the tumortissue.Ninety-six hours after intraperitoneal injection of

125

I-MGb

-DM conjugate

the ratio ofradioactivity per milligram of tumor to that per milligram of blood reached 203

the result beingquite similar to that of unmodified MGb

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Tumor localization of anti-gastric cancer monoclonal antibody MGb2-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

Tumor localization of anti-gastric cancer monoclonal antibody MGb2-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

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摘要

Abstract

关键词

Keywords

references

Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901

Tumor localization of anti-gastric cancer monoclonal antibody MGb₂-daunomycin conjugate in nude mice bearing human gastric carcinoma SGC-7901