Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin

杨军; 包军; 苏定冯

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Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin

Updated：2026-03-12

- Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin
- Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin
- 解放军医学杂志（英文版） 1991年第2期页码：123-126
- Affiliations：
  
  1. Department of Pharmacology Second Military Medical University
  2. ,Shanghai,200433
- Author bio：
- Funds：
  
  Project supported by the National Natural Science Foundation of China N 3880743
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin[J]. 解放军医学杂志（英文版）, 1991,(2):123-126.

[1]杨军,包军,苏定冯.Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin[J].Journal of Medical Colleges of PLA,1991(02):123-126.
Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin[J]. 解放军医学杂志（英文版）, 1991,(2):123-126. DOI：

[1]杨军,包军,苏定冯.Effects of serotonin and noradrenaline on neuronal activities of the solitary tract nucleus and its alteration after ketanserin[J].Journal of Medical Colleges of PLA,1991(02):123-126. DOI：

摘要

Abstract

<正> Effects of serotonin（5-HT）and noradrenaline（NA）on neuronal activities of the sol-itary tract nucleus（NTS）were investigated in rat medullary slice preparations.After perfusingthe slice with 5-HT

the spontaneous discharge was significantly increased in 25（of 43

58.1%）NTS neurons

reduced in 13（30.2%）and not changed in 5（11.7%）.After perfusingthe slice with NA

the spontaneous discharge was significantly reduced or even completelyceased in 27（62.8%）neurons

increased in 13（30.2%）and not changed in 3（7%）.Therewere 38（88.4%）neurons responding to both 5-HT and NA.From the 38 neurons

21 wereselected for studying the effect of ketanserin.It was found that ketanserin potentiated the ef-fect of NA on spontaneous discharge in 10（47.6%）neurons and attenuated it in 4（19.0%）neurons.These results suggest that there is an interaction between 5-HT receptorand α-adrenoceptor at the NTS level.This interaction may be helpful in explaining themechanism of the central antihypertensive action of ketanserin.

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