Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro

楼国良; 闵碧荷; 孟沛霖; 曹雪涛

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Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro

Updated：2026-03-12

- Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro
- Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro
- 解放军医学杂志（英文版） 1993年第2期页码：175-178
- Affiliations：
  
  1. Department of Hematology Changhai Hospital
  2. Second Military Medical University
  3. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro[J]. 解放军医学杂志（英文版）, 1993,(2):175-178.

[1]楼国良,闵碧荷,孟沛霖,曹雪涛.Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro[J].Journal of Medical Colleges of PLA,1993(02):175-178.
Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro[J]. 解放军医学杂志（英文版）, 1993,(2):175-178. DOI：

[1]楼国良,闵碧荷,孟沛霖,曹雪涛.Induction of LAK cells in acute leukemia patients and kinetics of LAK activity in long term culture in vitro[J].Journal of Medical Colleges of PLA,1993(02):175-178. DOI：

摘要

Abstract

正

Peripheral blood mononuclear cells（PBMNC）isolated from patients with acuteleukemia（AL）and from normal controls were cultured in a medium containing1000units/ml of recombinant interleukin-2（IL-2）.Marked LAK activity was induced onthe third culture day in the normal controls

with the highest cytotoxicity appearing be-tween day 3 and 5

whereas induction of LAK activity in the AL patients began on the5th day of culture

with a peak level appearing at day 15

showing that the peak ofLAK activity was significantly delayed in AL.LAK cells surface phenotyping tests showedthat CD

and CD

positive cells began to increase significantly from day 5 and reachedthe highest level at week 3

whereas CD

subclass began to decrease at day 5 anddropped to the nadir at week 3

indicating that LAK activity was positively correlatedwith the proportion of CD

and CD

cells

but negatively with that of CD

cells.

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