Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D<sub>3</sub> and Retinoic Acid

程涛; 严舫; 万景华; 殷建林

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Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid

Updated：2026-03-12

- Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid
- Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid
- 解放军医学杂志（英文版） 1990年第3期页码：282-286
- Affiliations：
  
  1. Department of Hematology Changhai Hospital
  2. Second Military Medical University
  3. ,Tianjin,300020
  4. Institute of Hematology
  5. Chinese Academy of Medical Sciences
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1990
- Accepted：
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Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid[J]. 解放军医学杂志（英文版）, 1990,(3):282-286.

[1]程涛,严舫,万景华,殷建林.Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D_3 and Retinoic Acid[J].Journal of Medical Colleges of PLA,1990(03):282-286.
Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid[J]. 解放军医学杂志（英文版）, 1990,(3):282-286. DOI：

[1]程涛,严舫,万景华,殷建林.Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D_3 and Retinoic Acid[J].Journal of Medical Colleges of PLA,1990(03):282-286. DOI：

摘要

Abstract

正

The effect of 1

25-dihydroxyvitamin D

25（OH）

] and13-cis-retinoic acid（RA）on the proliferation of a novel human megakaryoblasticleukemia cell line（HIMeg）was investigated.At the concentration of 10

mol/L

25（OH）

and RA showed significant inhibition of the proliferation of themegakaryoblastic leukemic cells

which was demonstrated by the count of survival cells

incorporation of

H-TdR and

H-UR

and cloning efficiency in dose-dependent and time-dependent manners.The results can further explain the mechanism of differentiation-inducing agents and the effect of 1

25（OH）

on myelofibrosis.It is possible for1

25（OH）

and RA to be used to treat malignant megakaryocytic diseases.

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Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D3 and Retinoic Acid

Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D3 and Retinoic Acid

DOI：

摘要

Abstract

关键词

Keywords

references

Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid

Inhibition of Proliferation of Human Megakaryoblastic Leukemic Cells by 1,25-Dihydroxyvitamin D₃ and Retinoic Acid