Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities

陈文晖; 段祥生; 许德余

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Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities

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- Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities
- Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities
- 解放军医学杂志（英文版） 1991年第4期页码：309-318
- Affiliations：
  
  1. Division of Medicinal Chemistry Laboratory for Antimalarial Drug Research
  2. Second Military Medical University
  3. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities[J]. 解放军医学杂志（英文版）, 1991,(4):309-318.

[1]陈文晖,段祥生,许德余.Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities[J].Journal of Medical Colleges of PLA,1991(04):309-318.
Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities[J]. 解放军医学杂志（英文版）, 1991,(4):309-318. DOI：

[1]陈文晖,段祥生,许德余.Separation and identification of the major components of Photocarcinorin and their tumor-photobiological activities[J].Journal of Medical Colleges of PLA,1991(04):309-318. DOI：

摘要

Abstract

正

It has been shown by the results-of HPLC analysis in combination with spectrographicdeterminations that PsD-007 is composed of 7 different porphyrins

In order of the proportion inPsD-007

they are:3 （or 8）-（l-methoxyethyl）-8 （or 3）-（l-hydroxyethyl）-deuteroporphyrin Ⅸ（MHD）;3

8-di-（l-methoxyethyl）-deuteroporphyrin Ⅸ（DMD）;3（or 8）-（l-methoxyethyl）-8 （or3）-vinyl-deuteroporphyrin Ⅸ（MVD）;3（or 8）-（l-hydroxyethyl）-8（or 3）-vinyl-deuteroporphyrin Ⅸ（HVD）;hernatoporphyrin Ⅸ （Hp）;protoporphyrin Ⅸ （Pp） and 3（or 8）-（O-aceylethyl）-8（or 3）-（l-hydroxyethyl）-deuteroporphrin Ⅸ （AHD）

which presented only in crude PsD-007 and hasbeen transformed into MHD and Hp

respectively during the separation and preparing the clinicalpreparation of PsD-007.Structures of these porphyrins were further eonfirmed by the corre-sponding anthentic samples obtained by synthetic method.It was found on the basis of the experi-mental data of photosensitizing ability in cell-free systems and photoinactivation of human cancercells in vitro as well as efficacy of photodynamic therapy for sarcoma.S

180

in mice of the ma-jor components MILD

DMD and MVD composed of which more over 85% of the totalamount of PsD-007

that they all exhibited comparatively high photosensitizing ability andphotodynamic effects on cancer cells and tram-planted animal tumor.

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