Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats

张乐之; 李英衢

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Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats

Updated：2026-03-12

- Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats
- Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats
- 解放军医学杂志（英文版） 1991年第1期页码：64-67
- Affiliations：
  
  1. Department of Pharmacology Third Military Medical College
  2. ,Chongqing,630038
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J]. 解放军医学杂志（英文版）, 1991,(1):64-67.

[1]张乐之,李英衢.Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J].Journal of Medical Colleges of PLA,1991(01):64-67.
Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J]. 解放军医学杂志（英文版）, 1991,(1):64-67. DOI：

[1]张乐之,李英衢.Mechanism of palliative effect of pethidine on tracheal hot air inhalation injury in rats[J].Journal of Medical Colleges of PLA,1991(01):64-67. DOI：

摘要

Abstract

<正> The increases of tracheal vascular permeability and malondialdehyde（MDA） content 1

2 and 3 h after introduction of hot air into the rat tracheaswere markedly inhibited by pethidine.The decreases of tracheal superoxidedismutase （SOD） activity 2 and 3h after hot air injury were elevated bypethidine.However

the inhibitory effect of pethidine on tracheal vascularpermeability was not antagonized by naloxone.This implies that opiate receptorsensitive to naloxone is not involved in the inhibitory effect of pethidine ontracheal vascular permeability.Pethidine could decrease MDA content and in-crease SOD activity.These antioxidative effects are beneficial to decreasingvascular permeability.

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