<正> In order to investigate the cardiovascular effects of the scorpion（Buthus martensiKarsch）venom（BmKv）

the left ventricle of the rats was catheterized via the right carotidartery.The LVP

LVEDP

+dp/dt max

Vmax

HR and BP were observed.The results showedthat intravenous injection of the BmKv（60μg/kg）

in comparison with the control

elicited obvi-ous hypertension and increase of cardiac contractility

both of which lasted for 1h

while theheart rate had no significant change rand that pretreating the rats with alpha-adrenergic blocker

phentolamine

antagonized the hypertensive effects

but did not antagonize the increase of cardiaccontractility.Pretreatment with beta-adrenergic blocker

propranolol

has no influence on the ef-fects of the venom.It is suggested that the hypertensive effects are due to the activation of al-pha-adrenergic receptor

whereas the increase of cardiac contractility may not be resulted fromthe activation of beta-adrenergic receptor.The BmKv treated with dithiothreitol before injectionhad no cardiovascular effects

indicating that the intact disulfide bridges play a decisive role inthe cardiovascular effects of the BmKv.