Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance

张晓东; 王文亮; 刘彦仿; 王伯沄

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Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance

Updated：2026-03-12

- Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance
- Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance
- 解放军医学杂志（英文版） 1992年第2期页码：136-140
- Affiliations：
  
  1. Department of Pathology Fourth Military Medical University
  2. ,Tianjin,300142
  3. The Hospital of PLA,254
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance[J]. 解放军医学杂志（英文版）, 1992,(2):136-140.

[1]张晓东,王文亮,刘彦仿,王伯沄.Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance[J].Journal of Medical Colleges of PLA,1992(02):136-140.
Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance[J]. 解放军医学杂志（英文版）, 1992,(2):136-140. DOI：

[1]张晓东,王文亮,刘彦仿,王伯沄.Distribution of HBV DNA and HBsAg in the liver of patients with liver cirrhosis and its significance[J].Journal of Medical Colleges of PLA,1992(02):136-140. DOI：

摘要

Abstract

<正> Hepatitis B virus（HBV）DNA and HBsAg were detected in 51 human paraf-fin-embedded sections of liver cirrhosis by the double labelling technique of in situ hybfidiza-tion and PAP method.The results showed that the positive sections were 21（41.2％）for HBVDNA

43（84.3％）for HBsAg and 19（37.3％）for both HBV DNA and HBsAg.HBV DNA-positivegrains were localized predominantly in the cytoplasm of hepatic cells or in both nucleus andcytoplasm

a few only in the nucleus or the inner side of the cell membrane.In active cirrhosisand inactive cirrhosis

the positive rates of HBV DNA were 52.8％ and 13.3％

respectively

andfor both HBV DNA and HBsAg

they were 47.2％ and 13.3％ restively.The positive rate ishigher in active cirrhosis than in inactive cirrhosis（P<0.05）.The results further indicated that theinfection of HBV and the existence and persistent action of HBV DNA in the liver tissues areone of the important factors of the development of liver cirrhosis.

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