Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro

仇玉福; 余立清

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Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro

Updated：2026-03-12

- Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro
- Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro
- 解放军医学杂志（英文版） 1991年第2期页码：166-169
- Affiliations：
  
  1. Department of Pathology Third Military Medical College
  2. ,Chongqing,630038
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro[J]. 解放军医学杂志（英文版）, 1991,(2):166-169.

[1]仇玉福,余立清.Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro[J].Journal of Medical Colleges of PLA,1991(02):166-169.
Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro[J]. 解放军医学杂志（英文版）, 1991,(2):166-169. DOI：

[1]仇玉福,余立清.Quantitative analysis of butyric acid-induced nuclear ultrastructural alterations in cells of human lung giant cell carcinoma in vitro[J].Journal of Medical Colleges of PLA,1991(02):166-169. DOI：

摘要

Abstract

<正> The effects of butyric acid（BA）on the nuclear ultrastructure of humanlung giant cell carcinoma（Strain PLA-801 D）were observed with digital imageprocessing.It was found that the length of the nuclear circumference of the tu-mor cells incubated with 2mmol of BA was approximately equal to that of thecontrol whereas the nuclear area was increased by 1.4times

which implies thatthe nuclear profile tends to become more regular after BA treatment.In addition

the optical density of the nuclei of the experimental group decreased significantlyas compared with that of the control

which indicates that the chromatin in thenuclei was decreased by BA.It was concluded on the basis of the findings thatBA may have a biological effect of reverse-transformation on the malignant cells.

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