Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever

刘彦仿; 晏培松; 杨守京

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Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever

Updated：2026-03-12

- Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever
- Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever
- 解放军医学杂志（英文版） 1993年第2期页码：188-191
- Affiliations：
  
  1. Department of Pathology Fourth Military Medical University
  2. ,Xi’an,710032
- Author bio：
- Funds：
  
  Project was supported by the National Natural Science Foundation of China No.38 970 335
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever[J]. 解放军医学杂志（英文版）, 1993,(2):188-191.

[1]刘彦仿,晏培松,杨守京.Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever[J].Journal of Medical Colleges of PLA,1993(02):188-191.
Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever[J]. 解放军医学杂志（英文版）, 1993,(2):188-191. DOI：

[1]刘彦仿,晏培松,杨守京.Lipofuscin in brains of patients and mice with epidemic hemorrhagic fever[J].Journal of Medical Colleges of PLA,1993(02):188-191. DOI：

摘要

Abstract

正

We have previously shown that the lipofuscin in the brain seems to have in-creased in amount in autopsy cases of epidemic hemorrhagic fever.The purpose of thisstudy was to testify if there is really such an increase.Lipfuscin in 10 sections from everybrain of 10 autopsy cases

stained with Sudan Ⅳ

Sudan black and H.E.

was carefully es-timated and found to be greatly increased as compared with the controls of the same agewithout brain disease.Animal experiment was also conducted on 15 sucking BALB/c miceby I.P.inoculation of 100 LD

（0.05ml）of strain Chen of hemorrhagic fever virus

andon 15 mice without inoculation as controls.No lipofuscin was detected in the controls.However

in the brains of experimental mice

lipofuscin was found to be markedly in-creased

especially in the necrotic cells.The findings suggest that the over-productionand deposition of lipofuscin may be a mild change caused by the virus and its related fac-tors

which might be enhanced by hypotension and shock.

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