Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）

沈念慈; 袁伯俊; 唐惠兰; 李保春; 刘俊平; 李燕平; 张璞

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Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）

Updated：2026-03-12

- Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）
- Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）
- 解放军医学杂志（英文版） 1990年第3期页码：215-221
- Affiliations：
  
  1. Laboratory for Antimalarial Drug Research and Department of Pathologic Anatomy
  2. Second Military Medical University Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1990
- Accepted：
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Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）[J]. 解放军医学杂志（英文版）, 1990,(3):215-221.

[1]沈念慈,袁伯俊,唐惠兰,李保春,刘俊平,李燕平,张璞.Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin(PsD-007)[J].Journal of Medical Colleges of PLA,1990(03):215-221+226.
Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin（PsD-007）[J]. 解放军医学杂志（英文版）, 1990,(3):215-221. DOI：

[1]沈念慈,袁伯俊,唐惠兰,李保春,刘俊平,李燕平,张璞.Studies on Preclinical Toxicology of a New Tumor Photolocalizing and Photochemotherapeutic Agent, Photocarcinorin(PsD-007)[J].Journal of Medical Colleges of PLA,1990(03):215-221+226. DOI：

摘要

Abstract

正

Photocarcinorin was prepared in our Lab and its composition was differentfrom that of any other hematoporphyrin photosensitizers by TLC and HPLC analyses.The 95% fiducial limits of iv LD in mice were 176-236 mg·kg

-1

.The iv MLD indogs was 171 mg·kg

-1

.The acute and subacutc toxic tests in 37 dogs showed that theintoxicated manifestations were characterized by a complex syndrome always seen inporphyrias.The biological

laboratory and histopathologic findings revealed that theliver

kidney and erythroeytic series were the target organs.The damages were dose-related and reversible within 2 wk.he phototoxicity was determined in mice with UV ra-diation and compared with that of HpD.The extent of its phototoxic reactions waslower than that of HpD’s.

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