Research review Study and application of monoclonal antibodies against herpes simplex virus

汪美先; 高谦; 秦克锋; 喻启桂; 沈茜; 唐家琪

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Research review Study and application of monoclonal antibodies against herpes simplex virus

Updated：2026-03-12

- Research review Study and application of monoclonal antibodies against herpes simplex virus
- Research review Study and application of monoclonal antibodies against herpes simplex virus
- 解放军医学杂志（英文版） 1991年第4期页码：383-387
- Affiliations：
  
  1. Laboratory of Molecular Virology Department of Microbiology
  2. Fourth Military Medical University
  3. ,Xi’an,710032
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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Research review Study and application of monoclonal antibodies against herpes simplex virus[J]. 解放军医学杂志（英文版）, 1991,(4):383-387.

[1]汪美先,高谦,秦克锋,喻启桂,沈茜,唐家琪.Research review Study and application of monoclonal antibodies against herpes simplex virus[J].Journal of Medical Colleges of PLA,1991(04):383-387.
Research review Study and application of monoclonal antibodies against herpes simplex virus[J]. 解放军医学杂志（英文版）, 1991,(4):383-387. DOI：

[1]汪美先,高谦,秦克锋,喻启桂,沈茜,唐家琪.Research review Study and application of monoclonal antibodies against herpes simplex virus[J].Journal of Medical Colleges of PLA,1991(04):383-387. DOI：

摘要

Abstract

<正> The results of research work completed in recent years in the authors’ laboratory withmonoclonal antibodies （McAbs） against herpes simplex virus （HSV） are reported in this paper as fol-lows.（1） Eighteen hybridoma cell lines steadily producing McAbs against HSV were established byhybridoma technic.（2） The mechanisms of neutralization in vitro and animal protection in vivo medi-ated by different McAbs were investigated.（3） A method of detecting virus antigua was developedwith the McAbs.（4） Tne isolates of virus were typed and antigenically analysed by type-specificand type-common McAbs.（5） HSV antigen in clinical spectimens was detected and directly typed byan ELISA method coating with type-specific and type-common McAb.（6） The target antigens ofMcAbs were identified

purified

and their genes were localized.（7） Experimental rabbitHSV keratitis was treated with McAbs.

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