Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis

刘玉峰; 刘彦仿; 丁华野; 张泰山; 樊平申; 廖文俊

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Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis

Updated：2026-03-12

- Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis
- Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis
- 解放军医学杂志（英文版） 1992年第1期页码：58-61
- Affiliations：
  
  1. Department of Dermatology Xijing Hospital
  2. Fourth Military Medical University
  3. ,Xi’an,710032
  4. Department of Pathology
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China No.38970687
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis[J]. 解放军医学杂志（英文版）, 1992,(1):58-61.

[1]刘玉峰,刘彦仿,丁华野,张泰山,樊平申,廖文俊.Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis[J].Journal of Medical Colleges of PLA,1992(01):58-61.
Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis[J]. 解放军医学杂志（英文版）, 1992,(1):58-61. DOI：

[1]刘玉峰,刘彦仿,丁华野,张泰山,樊平申,廖文俊.Dynamic observation of the effects of anti-keratin autoanti—bodies on the embedded autoepidermis[J].Journal of Medical Colleges of PLA,1992(01):58-61. DOI：

摘要

Abstract

<正> Autografts of skin of 3 rabbits were embedded in the subcutis of their backs.Samplingswere separately taken 2

10 and 12 d after grafting

A dynamic observation of the effectsof the anti-keratin autoantibodies（AK auto Ab）on the autoepidermis was made by HE

directimmunofluorescence（DIF）and peroxidase-antiperoxidase（PAP）stainings on frozen sections.It wasshown that the embedded autoepidermis could rapidly proliferate

extend and surround the keratinto form cysts.The specific IgG deposition was seen near the stratum corneum before the epidermiswas proliferated

and also there were obvious increases of IgG deposited in the granular layer ofproliferated epidermis

keratin and exfoliative keratinocytoplasm.But

after the keratin wascompletely blocked

it was found that the IgG decreased in the above areas.It is suggested that theconjugation of AK auto Ab with keratin may provide the earliest“biological information”of theabove-described reaction of epidermis.Dyskeratotic cells and hyaline corpuscles may be the resultsof interaction of the AK auto Ab of the exfoliative keratinocytes.

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