Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance

王文亮; W.Thomas London; Mark A.Feitelson

Your Location：

Home >

Browse articles >

Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance

Updated：2026-03-12

- Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance
- Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance
- 解放军医学杂志（英文版） 1992年第2期页码：114-120
- Affiliations：
  
  1. Department of Pathology Fourth Military Medical University
  2. ,USA
  3. Fox Chase Cancer Center
  4. Philadelphia
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
Scan QR Code
Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance[J]. 解放军医学杂志（英文版）, 1992,(2):114-120.

[1]王文亮,W.Thomas London,Mark A.Feitelson.Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance[J].Journal of Medical Colleges of PLA,1992(02):114-120.
Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance[J]. 解放军医学杂志（英文版）, 1992,(2):114-120. DOI：

[1]王文亮,W.Thomas London,Mark A.Feitelson.Expression of HBxAg in human chronic hepatitis,cirrhosis and primary hepatic carcinoma and its significance[J].Journal of Medical Colleges of PLA,1992(02):114-120. DOI：

摘要

Abstract

<正> The specimens of this study were obtained from 110 cases of chronic hepatitis

108cirrhosis and 110 primary hepatic carcinoma（PHC）.Formalin-fixed and paraffin-embedded seetions were stained by ABC method forHBxAg

and by PAP method for HRsAg and HBcAgOf the 110 cases of chronic hepatitis

72（65.5％）were positive HBxAg in the liver cells

66（60％）were postitive in HBsAg and 35（31.8％）in HBcAg.Among the 108 eases of drrhosis

84（77.8％）revealed to be HBxAg positive in the liver cells

73（67.6％）were demonstrated to beHBsAg-positive and 18（16.7％）were shown to be HBcAg-positive.Among the 110 eases of pri-mary hepatic carcinoma

64（58.2％）showed HBxAg-positive reaction in cancerous tissues.Therates of positive HRsAg and HBcAg in tumor tissues were 15.5％ and 10.9％

respectively.Six-ty-three（78.8％）of 80 cases of the non-cancerous hepatic tissues displayed HBxAg positivenessand the rates of positive HRsAg and HBcAg in the non-tumor tissues were 47（58.8％）and 21（2.6.3％）

respectively.The above-mentioned results sugared that the detection rote of HBxAg inchronic hepatitis

cirrhosis and PHC was higher than that of HBsAg and HBcAg.This studydemonstrates a dose relationship between chronic hepatitis

cirrhosis

PHC and chronic persistentinfection of hepatitis B virus（HBV）.Persistent chronic HBV infection plays an important role inthe pathogenesis of chronic hepatitis

cirrhosis and PHC.It is possible that the detection ofHBxAg with anti-HBx could be an additional new diagnostic marker for HBV infection.Howev-er

the role of HBxAg in the pathogenesis of chronic liver diseases needs to be furtherinvestigated.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据