Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[<sup>3</sup>H]—thymidine.uptake in mouse ascitic tumor cells

孙淑芬; 莫简; 郭正仁; 王多宁; 田琼; 刘健; 李之源

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Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells

Updated：2026-03-12

- Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells
- Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells
- 解放军医学杂志（英文版） 1992年第1期页码：1-6
- Affiliations：
  
  1. Departments of Chemistry Fourth Military Medical University Xi’an,710032
  2. Medical Radiology
  3. Central Laboratory
  4. Editorial Department of J Fourth Milit Med Univ
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China No.3860835
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells[J]. 解放军医学杂志（英文版）, 1992,(1):1-6.

[1]孙淑芬,莫简,郭正仁,王多宁,田琼,刘健,李之源.Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[~3H]—thymidine.uptake in mouse ascitic tumor cells[J].Journal of Medical Colleges of PLA,1992(01):1-6.
Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells[J]. 解放军医学杂志（英文版）, 1992,(1):1-6. DOI：

[1]孙淑芬,莫简,郭正仁,王多宁,田琼,刘健,李之源.Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[~3H]—thymidine.uptake in mouse ascitic tumor cells[J].Journal of Medical Colleges of PLA,1992(01):1-6. DOI：

摘要

Abstract

正

The effects of combined use of earthworm extract（912）and HpD-laser on the produc-tion of reactive oxygen and the biosynthesis of DNA in S

180

tumor cells were studied throughchemiluminescence measurement and[

H]-TdR incorporation assay.The results showed that as com-pared with the control

the intensity of chemiluminescence emitted by tumor cells treatedsimultaneously with 912 and HpD-laser was enhanced more than ten-folds

while that treated with912 or HpD-laser alone was increased only 2～4 folds.The[

H]-TdR incorporation into tumorcells of the former group was inhibited upto 74.1%

and that of the latter groups decreased onlyby 42.2% and 40.0%

respectively.In accordance with these biochemical changes

the ultrastructuraldamage of tumor cells of the former

combinedly treated group appeared to be the most serious.This suggests an additive effect of 912 with HpD-laser on tumor cells.In addition

if free radicalscavengers

such as catalase and superoxide dismutase

were added to the reaction systembefore chemiluminescence assay

the luminescent enhancement effect mentioned above was dramaticallyalleviated

implying the presence of O

and H

in the system.Therefore

as to the toxic effecton tumor cells

912 and HpD-laser are not only additive in efficiency

but also similar in theunderlying mechanism of action.

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Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[3H]—thymidine.uptake in mouse ascitic tumor cells

Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[3H]—thymidine.uptake in mouse ascitic tumor cells

DOI：

摘要

Abstract

关键词

Keywords

references

Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells

Additive effects of earthworm extract with HpD-laser on the enhancement of reactive oxygen production and the inhibition of[³H]—thymidine.uptake in mouse ascitic tumor cells