Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy

许德余; 陈文晖; 张浩; 沈念慈

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Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy

Updated：2026-03-12

- Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy
- Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy
- 解放军医学杂志（英文版） 1993年第4期页码：406-409
- Affiliations：
  
  1. Laboratory for Antimalarial Drug Research Second Military Medical University
  2. ,Shanghai,200433
- Author bio：
- Funds：
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- 纸质出版：1993
- Accepted：
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Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy[J]. 解放军医学杂志（英文版）, 1993,(4):406-409.

[1]许德余,陈文晖,张浩,沈念慈.Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy[J].Journal of Medical Colleges of PLA,1993(04):406-409.
Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy[J]. 解放军医学杂志（英文版）, 1993,(4):406-409. DOI：

[1]许德余,陈文晖,张浩,沈念慈.Hematoporphyrin 3-or 8-monomethyl ether:a promising candidate for tumor photodynamic therapy[J].Journal of Medical Colleges of PLA,1993(04):406-409. DOI：

摘要

Abstract

<正> Presented are methods for preparation

photosensitizing potential

photoinactivationof human cancer cells in vitro

efficacy of photodynamic therapy（PDT）of transplanted animaltumor and related data of preclinical and toxicological tests of a new single porphyrin compoundhematoporphyrin monomethyl ether（HMME）.The results of experiments indicated that in com-parison with the mixed porphyrin preparation（HpD）now used in clinical practice

HMMEproved to be of higher photosensitizing potential

stronger photodynamic effects

lower toxicitynonmutagenicity and nonteratogenicity

furthermore it can be selectively uptaken into tumor tis-sue in mice.It may be considered a new ideal drug candidate for tumor photodynamic therapy.

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