Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury

徐如祥; 易声禹; 刘少卿

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Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury

Updated：2026-03-12

- Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury
- Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury
- 解放军医学杂志（英文版） 1993年第2期页码：179-183
- Affiliations：
  
  1. Department of Neurosurgery Zhujiang Hospital
  2. First Military Medical University
  3. ,Guangzhou,510282
  4. Xijing Hospital
  5. fourth Military Medical University.,Xi’an,710032
  6. Department of Chemistry
  7. Fourth Military Medical University
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury[J]. 解放军医学杂志（英文版）, 1993,(2):179-183.

[1]徐如祥,易声禹,刘少卿.Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury[J].Journal of Medical Colleges of PLA,1993(02):179-183.
Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury[J]. 解放军医学杂志（英文版）, 1993,(2):179-183. DOI：

[1]徐如祥,易声禹,刘少卿.Effect of cyproheptadine on changes of 5-HT and 5-HIAA levels in brain cortex and serum following rat brain injury[J].Journal of Medical Colleges of PLA,1993(02):179-183. DOI：

摘要

Abstract

<正> Changes of 5-hydroxytryptamine（5-HT）and 5-hydroxyindoleacetic acid（5-HIAA）levels in brain cortex and serum were studied using spectrofluorometer follow-ing brain injury in rats.Cyproheptadine

a receptor antagonist of 5-HT

was employedand its effect on alterations of 5-HT and 5-HIAA contents in brain cortex and serum af-ter brain injury was investigated.The results showed that after brain injury levels of5-HT and 5-HIAA in the brain cortex increased markedly

The increase of 5-HT in thebrain cortex reached its peak at 48h after brain injury

and its value was 4.29±0.44μg/g

which was 4.8 times of control value.The increase of 5-HIAA in the brain cortexreached its peak at 24h after brain injury

and its value was 5.48±0.41μg/g

which was5.8times of control value.The change of 5-HT in the serum was not significant

but thelevel of 5-HIAA in the serum was increased significantly.Cyproheptadine could reducelevels of 5-HT and 5-HIAA in this experiment.The value of 5-HT in the brain cortexdecreased to 1.32±0.09μg/g

and the value of 5-HIAA decreased to 1.36±0.10μg/g.Thelevel of 5-HIAA in the serum was also reduced significantly.It was 0.27±0.03μg/ml.

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