An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro

丁彦青; 张进华; 李春德; 王小宁; 罗荣城

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An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro

Updated：2026-03-12

- An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro
- An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro
- 解放军医学杂志（英文版） 1993年第1期页码：34-38
- Affiliations：
  
  1. Department of Pathology
  2. 1
  3. and Biotechnology Centre
  4. 2
  5. First Military Medical University Guangzhou,510515
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro[J]. 解放军医学杂志（英文版）, 1993,(1):34-38.

[1]丁彦青,张进华,李春德,王小宁,罗荣城.An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro[J].Journal of Medical Colleges of PLA,1993(01):34-38.
An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro[J]. 解放军医学杂志（英文版）, 1993,(1):34-38. DOI：

[1]丁彦青,张进华,李春德,王小宁,罗荣城.An immunofluorescence study on the changes of microtubulin in human rectal adenocarcinoma cells killed by LAK cells in vitro[J].Journal of Medical Colleges of PLA,1993(01):34-38. DOI：

摘要

Abstract

<正> The human rectal adenocarcinoma cell line（HR8348）was treated withlympholdne activated killer（LAK）cells in vitro and the changes of the microtubulin inboth the effector and target cells were investigated with the aid of immunofluorescencemicroscopy.It was revealed that after the attachment of LAK cells to the tumor cells

theeffector-target conjugates formed and distribution of the microtubulin in both the effectorand target cells changed.In the LAK cells

the microtubulin concentrated mainly in thecontact region

forming a crescent-like structure

while in the target cells

themicrotubulin condensed into patches and fused with the crescent-like structure of the LAKcells

Eventually

the target cells degenerated and died.It was suggested that the lysis ofthe target cells may be related to the redistribution of the microtubulin in both theeffector and target cells.

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