The postsynaptic effect of taxol on rat neuromuscular junction

高天明; 陈肇熙; 孙文颖

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The postsynaptic effect of taxol on rat neuromuscular junction

Updated：2026-03-12

- The postsynaptic effect of taxol on rat neuromuscular junction
- The postsynaptic effect of taxol on rat neuromuscular junction
- 解放军医学杂志（英文版） 1991年第4期页码：348-352
- Affiliations：
  
  1. Department of Physiology First Military Medical University
  2. ,Guangzhou,510515
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1991
- Accepted：
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The postsynaptic effect of taxol on rat neuromuscular junction[J]. 解放军医学杂志（英文版）, 1991,(4):348-352.

[1]高天明,陈肇熙,孙文颖.The postsynaptic effect of taxol on rat neuromuscular junction[J].Journal of Medical Colleges of PLA,1991(04):348-352.
The postsynaptic effect of taxol on rat neuromuscular junction[J]. 解放军医学杂志（英文版）, 1991,(4):348-352. DOI：

[1]高天明,陈肇熙,孙文颖.The postsynaptic effect of taxol on rat neuromuscular junction[J].Journal of Medical Colleges of PLA,1991(04):348-352. DOI：

摘要

Abstract

<正> Taxol was used as a tool reagent and the function of the microtubules （MTs） beneath thepostsynaptic membrane was studied in an isolated non-uniformly stretched muscle preparation of ratdiaphragm.After exposure to taxol （20 μmol/L

10min）

the amplitude of acetylcholine potential ofinnervated muscle endplate was decreased by 30%

but the lime course of AChP and membrane po-tential remained unchanged.The results indicate that taxol can inhibit the responsiveness ofpostsynapfic membrane.It is therefore suggested that the site of action of taxol indudng inhibitionof postsynapfic responsiveness in neuromuscular junction may be the microtubules beneath thepostsynapfic membrane.

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