<正> Several studies suggest that Ginsenosides have a protective effect on myocardialischemia and reperfusion injury.Using the isolated working rat heart model the effect ofthe St.Thomas’ Hospital cardioplegic solution containing different concentrations ofGinsenosides on the enhancement of myocardial protection following hypothennic ischemicarrest（20 ℃

120min）was evaluated.The concentrations of Ginsenosides in thecardioplegic solutions were 0（control）

50

100

and 150μg/ml

respectively.Recoveries ofaortic flow

cardiac output

and minute work markedly improved by adding Ginsenosidesto cardioplegia.Dose-response tests indicated the best protective effect in the group using100 μg/ml

where the generation of thiobarbituric acid reactive materials（malondialdehyde

MDA）markedly reduced.These results showed that Ginsenosides may enhance themyocardial protection of the St.Thomas′ Hospital cardioplegic solution

and that additionof Ginsenosides to cardioplegia may protect the ischemic myocardium from free-radical in-jury.