Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes

王向东; 骆训懿; 李建新; 魏尧梅

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Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes

Updated：2026-03-12

- Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes
- Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes
- 解放军医学杂志（英文版） 1992年第1期页码：31-35
- Affiliations：
  
  1. Present address:Department of Oinical Laboratory Hospital of Beijing Command of PLA
  2. ,Shanghai,200433
  3. Department of Biochemistry
  4. Second Military Medical University
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes[J]. 解放军医学杂志（英文版）, 1992,(1):31-35.

[1]王向东,骆训懿,李建新,魏尧梅.Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes[J].Journal of Medical Colleges of PLA,1992(01):31-35.
Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes[J]. 解放军医学杂志（英文版）, 1992,(1):31-35. DOI：

[1]王向东,骆训懿,李建新,魏尧梅.Effects of derivatives of human glycophorin A and their antibodies on the recognition and invasion of Plasmodium falciparum into erythrocytes[J].Journal of Medical Colleges of PLA,1992(01):31-35. DOI：

摘要

Abstract

<正> Electrophoresis-purified human glycophorin A（GPA）was used to produce its derivatives:（1）separation and purification of glycopeptides from GPA were performed after trypsin-digestion:（2）prepanation of GPA antibody and GPA glycopeptide antibody;（3）preparation of deglycosylatedGPA（dGPA）;（4）incorporating GPA or dGPA into human RBC membrane lipids to form twokinds of liposomes.The products described above were used to test Plasmodim falciparumFCC-1/HN merozoites for their ability to invade human erythrocytes.It was found that GPA-liposomes were able to bind with merozoites and dGPA-liposomes had a negative reaction.GPA

GPA glycopeptide

GPA antibody

GPA glycopeptide antibody and GPA-liposome all had the effectto hinder the invasion of merozoites into human erythrocyte

whereas dGPA-liposome had no suchan effect.

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