Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors

毛庆武; 乌乃侯; 朱艳萍; 苗小飞

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Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors

Updated：2026-03-12

- Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors
- Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors
- 解放军医学杂志（英文版） 1992年第2期页码：103-108
- Affiliations：
  
  1. Department of Medical Protection Second Military Medical University
  2. ,Shanghai,200433
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors[J]. 解放军医学杂志（英文版）, 1992,(2):103-108.

[1]毛庆武,乌乃侯,朱艳萍,苗小飞.Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors[J].Journal of Medical Colleges of PLA,1992(02):103-108.
Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors[J]. 解放军医学杂志（英文版）, 1992,(2):103-108. DOI：

[1]毛庆武,乌乃侯,朱艳萍,苗小飞.Effect of soman on the neuro-muscle junctional and extrajunctional nicotinic acetylcholine receptors[J].Journal of Medical Colleges of PLA,1992(02):103-108. DOI：

摘要

Abstract

<正> Autoradiography of nicotinic acetytcholine receptors（N-ACHR）with the application ofhistochemical staining location of cholinesterase was used to observe the effect of soman onjunctional and extrajunctional N-AChR.Testing with the diaphragms and extensor digitorum longusmuscles of mice and rats

we found that soman mainly increased the number of extrajunctionalN-AChR.It did not alter the number of junctional N-AChR significantly

nor did it have any pro-nouneed effects on the gtycoprotein property and isoelectfic point（pI）of junctional andextrajunctional N-AChR.The change of extrajunctional N-AChR number caused by somanis similar to the phenomenon of increased extrajunctional N-AChR number and sensitivity resultingfrom denervation

but the mechanism of action is different from the latter.The increase ofN-AChR number is one of the important characteristics of soman poisoning which make it differ-ent from other nerve agents.To maintain the metabofic balance of N-AChR may be an importantnew approach to the treatment of soman poisoning.

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