A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer

王俊茹; 刘为纹; 吕有勇; 邓国仁

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A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer

Updated：2026-03-12

- A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer
- A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer
- 解放军医学杂志（英文版） 1993年第3期页码：220-225
- Affiliations：
  
  1. Department of Gastroenterology Southwest Hospital
  2. Third Military Medical College
  3. ,100034
  4. Beijing Institute for Cancer Research
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer[J]. 解放军医学杂志（英文版）, 1993,(3):220-225.

[1]王俊茹,刘为纹,吕有勇,邓国仁.A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer[J].Journal of Medical Colleges of PLA,1993(03):220-225.
A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer[J]. 解放军医学杂志（英文版）, 1993,(3):220-225. DOI：

[1]王俊茹,刘为纹,吕有勇,邓国仁.A study on the activation of 8 oncogenes and inactivation of 2 oncosuppressor genes in human gastric cancer[J].Journal of Medical Colleges of PLA,1993(03):220-225. DOI：

摘要

Abstract

<正> The changes of 8 oncogenes and 2 oncosuppressor genes in the specimens of cancer-ous and juxtacancerous tissues of 42 cases of gastric cancer were studied with southern blot hy-bridization and PCR-RFLP method.The probes used were c-Ha-ras

K-ras

N-ras

N-myc

c-myc

hst

EGFR

c-erbB-2

p53 and Rb.Amplification

rearrangement and deletion of c-Ha-ras were detected in 8/33 （24.2%） cases of gastric cancer

amplification or rearrangement ofhst and c-erbB-2 in 11/42 （26.2%） and 12/41 （29.2%） cases respectively

amplification ofEGFR in 9/42 （21.4%） cases

and deletion or rearrangement of p53 and Rb in 9/30 （30.0%）and 2/15 （13.3%） cases respectively.Amplification or rearrangement of N-ras （0/33）

K-ras（1/26）

N-myc （1/26）

and c-myc （1/35）was rarely encountered.These findings suggest thatc-Ha-ras

hst

c-erbB-2

EGFR and p53 may be important genes involved in the pathogenesisof gastric cancer.

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