A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats

孙文兵; 韩本立; 李昆; 段恒春; 王加文; 尹国清

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A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats

Updated：2026-03-12

- A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats
- A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats
- 解放军医学杂志（英文版） 1992年第2期页码：109-113
- Affiliations：
  
  1. Department of Hepatobiliary Surgery Southwest Hospital
  2. Third Military Medical College
  3. ,Chongqing,630038
- Author bio：
- Funds：
  
  The project was supported by thd National Natural Science Foundation of China
- DOI：
  中图分类号：
- 纸质出版：1992
- Accepted：
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A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats[J]. 解放军医学杂志（英文版）, 1992,(2):109-113.

[1]孙文兵,韩本立,李昆,段恒春,王加文,尹国清.A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats[J].Journal of Medical Colleges of PLA,1992(02):109-113.
A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats[J]. 解放军医学杂志（英文版）, 1992,(2):109-113. DOI：

[1]孙文兵,韩本立,李昆,段恒春,王加文,尹国清.A study of hepatic energy metabolism disturbance and its management in acute obstructive cholangitis in rats[J].Journal of Medical Colleges of PLA,1992(02):109-113. DOI：

摘要

Abstract

<正> The mitechondrial respiratory rate（S）of hepatocytes

respiratory control ratio（RCR）

oxidative phosphorylation effidency（ADP/O）

and hepatic ATP level were determined in ratswith acute obstructive cholangitis（AOC）to observe the changes of mitochondrial respiration

andthe therapeutic effects of verapamil and dexamethasone on the changes were assessedIt was found that S especially its state IV was significantly accelerated and RCR

ADP/O

and ATP level of the liver decreased at 6h after AOC

but in those rats treated with verapamilor dexamethasone

no significant changes of these parameters were observed in 48 h period afterAOC.These facts suggest that in the early stage of AOC

severe impairment of the mitochondrialrespiratory function and disturbance of energy metabolism could be present

but verapamil anddexamethasone could effectively prevent these damages from occurring.

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