<sup>131</sup>I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice

陈志南; 刘彦仿; 隋延仿; 付承华; 徐力青

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¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice

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- ¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice
- ¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice
- 解放军医学杂志（英文版） 1993年第2期页码：136-140
- Affiliations：
  
  1. Department of Pathology Fourth Military Medical University
  2. ,Xi’an,710032
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J]. 解放军医学杂志（英文版）, 1993,(2):136-140.

[1]陈志南,刘彦仿,隋延仿,付承华,徐力青.~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J].Journal of Medical Colleges of PLA,1993(02):136-140.
¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J]. 解放军医学杂志（英文版）, 1993,(2):136-140. DOI：

[1]陈志南,刘彦仿,隋延仿,付承华,徐力青.~(131)I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice[J].Journal of Medical Colleges of PLA,1993(02):136-140. DOI：

摘要

Abstract

正

Anti-hepatoma monoclonal antibodies HAb8

HAb18 IgG and HAb18 F（ab’）

were labelled with[

131

I]according to chloramine T method.The labelling rate andradioactivity were 51% and 9.58×10

Bq/mg

respectively.After administration of the[

131

I]-labelled conjugates through mouse tail vein

hepatoma xenografts were clearly im-aged

Localization index was 2.15

3.09

and 6.99 for HAb8

HAb18 IgG and HAb18F（ab’）

respectively.A total of 16 hepatoma-bearing nude mice（SMMU-LTNM）were di-vided into 4 groups.When xenografts reached 0.3cm in diameter

the treatment was be-gun by injection of the[

131

I]-conjugates through mouse tail vein.After 2 weeks of treat-ment

obvious inhibitory or killing effects on the xenografts were found.The tu-mor-bearing mice were killed during the period from 14 to 21d after treatment.Xenografts as well as other organs were sampled and viewed under light microscope ac-cording to routine procedure.The vital organs

such as heart

liver

spleen

lung

kidneyand brain showed no pathological lesions.In hepatoma xenografts

some tumor cellmembranes were found

with obscure cytoplasmic structure and increased eosinophilia

representing necrotic alterations.

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131I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice

131I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice

DOI：

摘要

Abstract

关键词

Keywords

references

¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice

¹³¹I-labelled anti-hepatoma monoclonal antibodies in targeting therapy of hepatoma xenografts in nude mice