A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection

郑红; 李奇芬; 吴纯清; 李梦东; 林晓红; 崔恒苒; 崔大敷; 黄维德

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A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection

Updated：2026-03-12

- A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection
- A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection
- 解放军医学杂志（英文版） 1993年第4期页码：391-394
- Affiliations：
  
  1. Department of Infectious Diseases Southwest Hospital
  2. Third Military Medical College
  3. Gaotanyan
  4. ,Shanghai,200031
  5. Institute of Biochemistry
  6. National Academy of Science of China
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1993
- Accepted：
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A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection[J]. 解放军医学杂志（英文版）, 1993,(4):391-394.

[1]郑红,李奇芬,吴纯清,李梦东,林晓红,崔恒苒,崔大敷,黄维德.A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection[J].Journal of Medical Colleges of PLA,1993(04):391-394.
A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection[J]. 解放军医学杂志（英文版）, 1993,(4):391-394. DOI：

[1]郑红,李奇芬,吴纯清,李梦东,林晓红,崔恒苒,崔大敷,黄维德.A synthetic oligopeptide of HDV antigen and its diagnostic application in HDV infection[J].Journal of Medical Colleges of PLA,1993(04):391-394. DOI：

摘要

Abstract

<正> A fragment of hepatitis delta antigen（HDAg）

a 27-peptide

was synthesized andused to develop an ELISA for the diagnosis of hepatitis delta virus（HDV）infection.It was foundthat positive anti-HD reaction occurred in the 27-peptide coated microtiter well after a sample ofstored serum known to be anti-HD positive was added. Neutralization test revealed that the pep-tide competed with natural HDAg for anti-HD

indicating the similarity of the antigenicity be-tween the peptide and natural HDAg.The peptide was quite specific in its antigenicity withoutcross reaction with normal human or mouse serum or with human anti-HA

anti-HB or anti-HCpositive serum.When the peptide was used clinically

1 anti-HD positive case among 300 blooddonors and 21 anti-HD positive cases among 211 cases of various forms of hepatitis B were detect-ed with the 27-peptide.

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