Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice

晏建军; 沈锋; 吴孟超

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Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice

Updated：2026-03-12

- Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice
- Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice
- 解放军医学杂志（英文版） 1997年第2期页码：132-135
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  中图分类号： R73-36
- 纸质出版：1997
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Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice[J]. 解放军医学杂志（英文版）, 1997,(2):132-135.

[1]晏建军,沈锋,吴孟超.Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice[J].Journal of Medical Colleges of PLA,1997(02):132-135.
Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice[J]. 解放军医学杂志（英文版）, 1997,(2):132-135. DOI：

[1]晏建军,沈锋,吴孟超.Experimental study on immunomodulation and antitumor effects of melatonin in H22 hepatoma-bearing mice[J].Journal of Medical Colleges of PLA,1997(02):132-135. DOI：

摘要

Abstract

Objective: To observe immunomodulation and antitumor effect of melatonin （MLT） in tumor-bearingmice. Methods: By means of flow cytometry and MTT colorimetry

the immunological indexes of H22 hepatoma-bearing mice were investigated. Results: MLTadministration could increase the CD4t/CD8t cell ratio in the pe-ripheral blood of the tumor-bearing mice

cooperate with IL-2 to promote the proliferation of lymphocytes andeosinophils

increase NK and LAK activity of splenocytes

and enhance the production of IL-2 from splenocytes.We also found that MLT could inhibit tumor growth and prolong the survival time of the tumor-bearing mice in vi-vo. Moreover

a synergetic effect of IL-2 and MLT was observed. It seems that MLT hadno effect on H22 hep-atoma cell growth in vitro. Conclusion: It is suggested that MLT may be a potential candidate for tumor im-munotherapy as one of the biological reaction modulators （BRM）.

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