In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells

于敏; 曹雪涛; 章卫平; 杨建民; 孟沛霖

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In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells

Updated：2026-03-12

- In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells
- In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells
- 解放军医学杂志（英文版） 1997年第2期页码：96-99
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  中图分类号： R730.2
- 纸质出版：1997
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In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells[J]. 解放军医学杂志（英文版）, 1997,(2):96-99.

[1]于敏,曹雪涛,章卫平,杨建民,孟沛霖.In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3 gene co-transfected leukemia cells[J].Journal of Medical Colleges of PLA,1997(02):96-99.
In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3gene co-transfected leukemia cells[J]. 解放军医学杂志（英文版）, 1997,(2):96-99. DOI：

[1]于敏,曹雪涛,章卫平,杨建民,孟沛霖.In vitro proliferation and in vivo tumorigenicity of IL-2 gene and IL-3 gene co-transfected leukemia cells[J].Journal of Medical Colleges of PLA,1997(02):96-99. DOI：

摘要

Abstract

In vitro proliferation and in vivo tumorigenicity of IL-2 and/or IL-3 gene transfected FBL-3erythroleukemia cells were observed to investigate the anti-tumor effect of tumor vaccine. Methods: Leukemiacells were trans fected with IL-2 and/or IL-3 adenovlrus vector. The cytokine expressions were assayed

and the growth characteristics of the transfected FBL-3 cells were studied. Results: High levels of secreted IL-2 and IL-3remained for one week after transfection

and the trans fected leukemia cells became unchanged in growth in vitro and showed weak tumorigenicity in vlvo. The tumorigenicity of FBL-3 cells decreased more significantly when FBL-3 cells were transfected with both IL-2 gene and IL-3 gene than when FBL-3 cells were tran fected with IL-2or IL-3 gene only. The tumor growth was significantly delayed and survival time of the trans fected FBL-3 inoculat ed mice was significantly prolonged. Conclusion: The inhibition of tumor growth is most likely dependent on immune response induced by IL-2

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