Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44

郭德玉; 陈意生; 卞修武; 史景泉; 陈自强

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Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44

Updated：2026-03-12

- Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44
- Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44
- 解放军医学杂志（英文版） 2002年第4期页码：247-250
- Affiliations：
  
  1. Institute of Pathology
  2. Southwest Hospital
  3. Third Military Medical University
  4. ,China
- Author bio：
- Funds：
  
  National Natural Science Foundation of China （No. 39670296）
- DOI：
  中图分类号： R73-3
- 纸质出版：2002
- Accepted：
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Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44[J]. 解放军医学杂志（英文版）, 2002,(4):247-250.

[1]郭德玉,陈意生,卞修武,史景泉,陈自强.Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44[J].Journal of Medical Colleges of PLA,2002(04):247-250+259.
Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44[J]. 解放军医学杂志（英文版）, 2002,(4):247-250. DOI：

[1]郭德玉,陈意生,卞修武,史景泉,陈自强.Study of apoptosis induced by nordihydroguaiaretic acid in human malignant glioma cell line SHG-44[J].Journal of Medical Colleges of PLA,2002(04):247-250+259. DOI：

摘要

Abstract

<正> Objective: To investigate the effect and mechanism of nordihydroguaiaretic acid （NDGA） on apop-tosis in human malignant glioma cell line SHG-44. Methods: Cell growth inhibition was measured with MTT assay. Cell apoptosis was observed with light and electron microscopy and TUNEL. Expression of bcl-2 gene was measured with immunohistochemistry

in situ hybridization and image analyses. Results: NDGA at the concentration of 100 μmol/L inhibited the proliferation of SHG-44 cells and induced apoptosis in a time-dependent manner. The expression of Bcl-2 protein in SHG-44 cells was decreased in the present of 100 μmol/L NDGA along with the duration of treatment in a negative correlation with the degree of cell apoptosis. The bcl-2 mRNA expressed in SHG-44 cells was reduced after treatment with 100 μmol/L NDGA

apparently consistent with the immunohistochemical results. Conclusion: NDGA can induce apoptosis of human malignant glioma cells probably by down-regulating expression of bcl-2 gene

though the exact

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